CRISPR is rightly celebrated — a Nobel Prize, the first approved cures, a tool of breathtaking elegance and reach. It is one of the genuine triumphs of our era. And precisely because it works so well, it has opened questions that are not scientific but moral, and that we have not answered — questions about what we should do with a power we now demonstrably have.
Several frontiers remain wide open, and they sharpen as the technology improves. Scientifically: CRISPR can make off-target edits — cutting at unintended sites elsewhere in the genome — and ensuring precision, and delivering the tool safely to the right cells in the body, are still being worked out. But the deeper unresolved questions are ethical. There is a profound line between editing the cells of a consenting patient to treat their disease, and editing germline cells — eggs, embryos, sperm — so that the changes pass to every future generation, rewriting the human inheritance itself. In 2018 a scientist crossed that line, creating gene-edited babies, and was widely condemned and imprisoned — but the episode proved the power is real and the temptation is here now. Should we edit traits that aren't diseases? Who decides which genes are "defects"? Who will have access, and who will be left behind or left out? These are not questions science can answer; they require wisdom science does not supply. We have acquired, suddenly, the ability to reach into the code of life — including our own — and we are discovering that the power to edit ourselves is not the same as the wisdom to know how we should. The tool took barely a decade to master; the wisdom to know when not to use it is nowhere near finished.
Job, in the middle of the most searching poem in Scripture about knowledge, stops and asks: "But do people know where to find wisdom? Where can they find understanding?" The whole chapter marvels at human cleverness — we mine the earth, dam rivers, master hidden things — and then drives home the gap: technical mastery is not wisdom, and the two come from different places. Job concludes that wisdom is found only in the fear of the Lord. CRISPR makes that ancient point newly urgent. We have, in a stunningly short time, gained a power our ethics have not caught up to — exactly the situation Job names. The ability is ours; the wisdom to wield it rightly is not something the laboratory can produce. It has to be received, in humility, from the One who authored the code we are now able to cut.
There is a temptation that grows with competence and age: to assume that because we can do a thing — fix it, control it, optimize it, reshape it to our preference — we therefore should, and that the having of power settles the question of its use. CRISPR is the sharpest possible case, but the temptation runs through ordinary adult life: in how we parent, how we wield influence, how we reshape our bodies and circumstances and the people around us to our liking. The power to edit is seductive precisely because it feels like wisdom; it is not. Job's question is meant to stop us in exactly that gap: where can wisdom be found? Not in the expanding reach of what we can do, but in the fear of the Lord — in returning the question of how to use our power to the God whose creation it edits, and whose understanding is the only thing deep enough to guide a power this great. The gift is real. So is the awe it should put in us. Handle it on your knees.